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Authored by Inho Nam Abstract Recent applications of microdroplet reactions are noted as reaction acceleration in confined environments and possible future scale-up synthesis compare to that of bulk phase reactions. Microdroplet reactions overcome the thermodynamic and kinetic challenges in an aqueous solution. Due to the microdroplet’s distinctive surface environment, the chemistry in Microdroplets significantly differs from that in the bulk solution. Keywords: Microdroplet; Noncovalent complexations; Electrostatic potential; Organic reactions Introduction Remarkable findings intrigued people in different fields by showing that extremely slow bulk phase reactions can be accelerated dramatically in aqueous microdroplets [1,2]. Not only the rate of the reaction but also the yields of reaction increased due to negative free-energy change which i
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