Juniper Publishers: Public Health Interventions in Cystic Fibrosis-Jun...

Juniper Publishers: Public Health Interventions in Cystic Fibrosis-Jun...: International Journal of Pulmonary & Respiratory Sciences   The United States invests billions of dollars dedicated to funding ...

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Polymeric Materials for the Development of Dual↓Working Gastroretentive Drug Delivery Systems. A Breakthrough Approach

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   JUNIPER PUBLISHERS-   ACADEMIC JOURNAL OF POLYMER SCIENCE Abstract Oral route is the most convenient and widely used method of drug administration, representing about 90% of all therapies used. It displays great advantages, such as being non-invasive, easy to administer (with the consequent high patient compliance) and cost-effective. However, serious drawbacks to conventional oral dosage forms are imposed by the gastrointestinal tract. Large fluctuations in drug bioavailability are found due to the influence of physiological factors such as variations in pH, high enzymatic activity and gastric emptying. This is the reason why frequent drug administrations are required to maintain the therapeutic plasma level of the drug. Gastroretentive Drug Delivery Systems (GRDDS) have emerged as an ideal approach to overcome these drawbacks. They are designed to prolong the gastric residence time (GRT) of the dosage forms in the stomach so that the time between dose administration is lengthened.
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Microdroplet Chemistry: Difference of Organic Reactions between Bulk Solution and Aqueous Microdroplets-Juniper Publishers

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Authored by Inho Nam                                                                                          Abstract Recent applications of microdroplet reactions are noted as reaction acceleration in confined environments and possible future scale-up synthesis compare to that of bulk phase reactions. Microdroplet reactions overcome the thermodynamic and kinetic challenges in an aqueous solution. Due to the microdroplet’s distinctive surface environment, the chemistry in Microdroplets significantly differs from that in the bulk solution. Keywords: Microdroplet; Noncovalent complexations; Electrostatic potential; Organic reactions Introduction Remarkable findings intrigued people in different fields by showing that extremely slow bulk phase reactions can be accelerated dramatically in aqueous microdroplets [1,2]. Not only the rate of the reaction but also the yields of reaction increased due to negative free-energy change which i
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