Gellan Gum Immobilized Anticancer Drugs and Gold Nanoparticles in Nanomedicine-Juniper Publishers
JUNIPER PUBLISHERS- ACADEMIC JOURNAL OF POLYMER SCIENCE Abstract This review is devoted to recent progress in the design of anticancer drug delivery systems with participation of unique polysaccharide gellan gum. At first a brief literature survey on conformational and phase behavior of gellan gum as a function of external stimuli, such as temperature, pH, salt addition etc. is presented. Then the immobilization protocol of anticancer drugs and gold nanoparticles within gellan-based hydrogel matrix is discussed. Release of anticancer drugs from gellan gel matrix to outer solution is considered. Cytotoxicity of gellan gum-immobilized gold nanoparticles together with their anticancer activity...