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Polymeric Materials for the Development of Dual↓Working Gastroretentive Drug Delivery Systems. A Breakthrough Approach

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   JUNIPER PUBLISHERS-   ACADEMIC JOURNAL OF POLYMER SCIENCE Abstract Oral route is the most convenient and widely used method of drug administration, representing about 90% of all therapies used. It displays great advantages, such as being non-invasive, easy to administer (with the consequent high patient compliance) and cost-effective. However, serious drawbacks to conventional oral dosage forms are imposed by the gastrointestinal tract. Large fluctuations in drug bioavailability are found due to the influence of physiological factors such as variations in pH, high enzymatic activity and gastric emptying. This is the reason why frequent drug administrations are required to maintain the therapeutic plasma level of the drug. Gastroretentive Drug Delivery Systems (GRDDS) have emerged as an ideal approach to overcome these drawbacks. They are designed to prolong the gastric residence time (GRT) of the dosage forms in the stomach so that the time between dose administration ...
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Research of Hydrogen Absorption-Desorption by Ti-Al-Nb Alloy-Juniper Publishers

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Authored by Kurbanbekov ShR                                                                             Abstract The paper presents kinetics of hydrogen sorption of Ti-23.5at%Al-21.5at%Nb alloys in isothermal conditions underthe temperature of 450, 500 and 550 °С. It was determined that maximum quantity of absorbed hydrogen is observed at material of sorbed alloy under the temperature of 550 °С. That presents approximately 0.289mass%. It had been found that hydrogen is released under the temperatures within 700 …790 °С. In addition, it was revealed that maximum release of hydrogen composes 85% of samples saturated...
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